In one small scale clinical trial of depressed patients, an improvement of symptoms which included anxiety, lack of drive and desire was observed.  In patients with dysthymia , unipolar , and bipolar depression significant improvement was observed.  In this series of studies, mesterolone lead to a significant decrease in luteinizing hormone and testosterone levels.  In another study, 100 mg mesterolone cipionate was administered twice monthly.  With regards to plasma testosterone levels, there was no difference between the treated versus untreated group, and baseline luteinizing hormone levels were minimally affected. 
Potential side effects are different between men and women. Common effects seen in men is jaundice, baldness, acne, breast tissue development, permanent liver damage and/or liver tumors and heart problems. Common side effects for women include jaundice, permanent deepening of their voice, increased facial hair, acne, permanent liver damage, heart problems and problems with their menstrual cycle. This list is not exhaustive, there are several other short and long-term side effects that are caused by steroid use. Most of the effects will gradually get better after cessation of the drug. However, there are grave and permanent risks involved whether the anabolic steroid is taken orally or with an injection.
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