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The pharmacokinetics of dalfampridine was studied in 9 male and 11 female subjects with varying degrees of renal function. Elimination of the drug is significantly correlated with the creatinine clearance. Total body clearance of dalfampridine was reduced by about 45 % in patients with mild renal impairment (CrCl 51-80 mL/min), by about 50% in patients with moderate renal impairment (CrCl = 30-50 mL/min), and by about 75% in patients with severe renal impairment (CrCl <30 mL/min). The terminal half-life of dalfampridine is about times longer in patients with severe renal impairment but is not prolonged in patients with mild or moderate renal impairment.