found an increased risk too, albeit quite a bit smaller (around x), A big problem with studies of this nature is that hormones are so widely used in women’s medicine, that by now it must be difficult to put together a truly unexposed control group. That probably at least partly accounts for why some studies are finding a greatly increased risk of hypospadias, and others not so much. In any case, there does appear to be a definite increased risk for hypospadias in DES grandsons, which is important as far as your question is concerned, because hypospadias is a marker for abnormally low prenatal androgen levels.
If you are switching to or from Spironolactone (Aldactone) and Cyprotone Acetate (Androcur) be aware that Androcur is much more powerful as an anti-androgen than Spiro, therfore you don't need to take as much of it. The general rule of thumb for conversion between the two is that Androcur is FOUR TIMES as strong as Spironolactone. So, if you were taking 200mg/day of Spiro that would mean you'd only need 50mg/day of Androcur. It is also suggested that you ramp down off of or up onto Spiro over the course of two to three weeks and start with no more than 25mg/day of Androcur until you are certain you do not have any negative reactions to it. It is important to have your liver function monitored while taking Androcur. Also be aware that people who switch from Spiro to Androcur also often notice a weight gain of between 5 and 20 pounds. Some of it is water weight returning once the diuretic effects of Spiro dissipate.
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