It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
When Jesus discusses marriage, he points out that there is some responsibility for a man marrying a woman (and vice versa). Not having assets of their own, women needed to be protected from the risk of their husbands' putting them on the street at whim. In those times marriage was an economic matter  rather than one of love. A woman and her children could easily be rejected. [ citation needed ] Restriction of divorce was based on the necessity of protecting the woman and her position in society, not necessarily in a religious context, but an economic context.  He also points out that there are those "which were made eunuchs of men: and there be eunuchs, which have made themselves eunuchs for the kingdom of heaven's sake", but in the original Greek, the word εὐνοῦχος means "castrated person". It was the custom at the time Jesus lived for priests of some ancient gods and goddesses to be castrated.  In the pre-Christian period Vestals , who served the virgin goddess of the hearth , were obliged to forgo marriage, and so were some priests and servants of some ancient deities such as Isis .  Jewish priests are allowed to marry. However, they are not allowed to marry a divorcee or certain other classes of women, or, in the case of a high priest, a widow (Leviticus 21:7, 8, 14 and 15).