It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
Depending on the individual goals a beginner will find comfortable Turinabol doses in the range of 15 – 30mg per day, although this is considered a low dose range where gains will not be exceptionally dramatic by any means. Such a Turinabol dose would provide noticeable but steady lean gains and almost nothing in the way of unwanted side effects except for those most sensitive. Intermediate users would find greater progress in the way of strength and mass gains upwards of 30 – 50mg per day with still very low incidences or chances of unwanted side effects. Advanced Turinabol doses land in the range of 50 – 80mg per day sometimes higher which would of course provide more dramatic strength and mass gains but at the expense of increased androgenic side effects at such an increased Turinabol dose. In general most users find satisfactory results in the middle of the total previously mentioned doses, which would be around 50mg per day. Doses lower than 40mg per day tend to be utilized merely for the preservation of lean mass during fat loss and cutting phases.