Decanoic acid acts as a non-competitive AMPA receptor antagonist at therapeutically relevant concentrations, in a voltage- and subunit-dependent manner, and this is sufficient to explain its antiseizure effects.  This direct inhibition of excitatory neurotransmission by decanoic acid in the brain contributes to the anticonvulsant effect of the MCT ketogenic diet .  Decanoic acid and the AMPA receptor antagonist drug perampanel act at separate sites on the AMPA receptor, and so it is possible that they have a cooperative effect at the AMPA receptor, suggesting that perampanel and the ketogenic diet could be synergistic. 
Through the consumption of the supplements of the present invention, a measureable increase in blood ketones can often be observed within hours of taking the supplements. This is particularly true if the subject maintains a ketogenic diet while taking the supplements. Thus, whereas it may take weeks to measure an increase of blood ketones following a ketogenic diet alone, the utilization of the present invention will allow the increase of blood ketones to be measured quickly, thereby encouraging and motivating those pursuing a state of ketosis.
Sodium bicarbonate (NaHCO 3 ) is a weaker base than sodium hydroxide. Thus, if your unknown does not dissolve in 5% sodium hydroxide there is no reason to test its solubility in a solution of sodium bicarbonate. However, if your unknown does dissolve in the hydroxide solution, it is useful to test the solubility in sodium bicarbonate since sodium bicarbonate will deprotonate functional groups with a pKa < 8, but not those with a pKa > 8 (Scheme 3). Thus, if your unknown dissolves in the aqueous NaOH, but does not dissolve in aqueous NaHCO 3 , it probably has a functional group with a pKa of between 8 and 14, possibly a phenol. If, on the other hand, your unknown is soluble in the bicarbonate solution, it is likely to have an acidic group with a pKa < 8, probably a carboxylic acid.